姓名:章晓联
单位:manbetx万博
manbetx万博
基础manbetx官方在线登录
免疫学系,湖北省过敏及免疫相关疾病重点实验室
职称:系主任及重点实验室主任、教授、博导
邮箱:zhangxiaolian@whu.edu.cn
联系电话:027-68750067
研究方向:
1.糖基化修饰与免疫:主要关注和揭示糖基化修饰、糖苷和凝集素在感染、肿瘤免疫识别和逃逸中的关键功能。
2.感染免疫:人类重要病原微生物(丙肝、结核等)慢性感染、致病及免疫逃逸机制研究;设计和研制了特异结合这些病原微生物/肿瘤细胞表面糖苷的药物分子、糖基化抑制剂、有效诊断试剂和疫苗。
代表性论著:
1.Wang SR, Min YQ, Wang JQ, Liu CX, Fu BS, Wu F, Wu LY, Qiao ZX, Song YY, Xu GH, Wu ZG, Huang G, Peng NF, Huang R, Mao WX, Peng S, Chen YQ, Zhu Y, Tian T, Zhang XL*, Zhou X*. (2016) A highly conserved G-rich consensus sequence in Hepatitis C virus core gene represents a new anti-Hepatitis C target, Science Advances, 2(4): e1501535.
2.Sun X, Pan Q, Yuan C, Wang Q, Tang XL, Ding K, Zhou X, Zhang XL*. (2016) A Single ssDNA Aptamer Binding to Mannose-Capped Lipoarabinomannan of Bacillus Calmette-Guérin Enhances Immunoprotective Effect against Tuberculosis. J Am Chem Soc. 138(36):11680-9.
3.Pan Q, Wang Q, Sun X, Xia X, Wu S, Luo F, Zhang XL*. (2014). Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys. Mol Ther. 22(5):940-51.
4. Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, Li Q, Zhang XL*. (2014). Ficolin-2 inhibits Hepatitis C Virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol. 193(2):783-96.
5.Xiang T, Yang G, Liu X, Zhou Y, Fu Z, Lu F, Gu J, Taniguchi N, Tan Z, Chen X, Xie Y, Guan F, Zhang XL*. (2017) Alteration of N-glycan expression profile and glycan pattern of glycoproteins in human hepatoma cells after HCV infection. Biochim Biophys Acta. 861(5 Pt A):1036-1045.
6.Yang YF, Zhou YD, Hu JC, Luo FL, Xie Y, Shen YY, Bian WX, Yin ZN, Li HL, Zhang XL*.(2017) FCN-A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis. Immunology Apr 5. doi: 10.1111/imm.12741.
7.Qian XJ#, Zhang XL#, Zhao P, Jin YS, Chen HS, Xu QQ, Ren H, Zhu SY, Tang HL, Zhu YZ, Qi ZT. (2016) A Schisandra-Derived Compound Schizandronic Acid Inhibits Entry of Pan-HCV Genotypes into Human Hepatocytes. Sci Rep. 6:27268.
8.Tang XL, Wu SM, Xie Y, Song N, Guan Q, Yuan C, Zhou X, Zhang XL*. (2016) Generation and application of ssDNA aptamers against glycolipid antigen ManLAM of Mycobacterium tuberculosis for TB diagnosis. J Infect, 72(5):573-586.
9.Ren Y, Min YQ, Liu M, Chi L, Zhao P, Zhang XL*.(2016) N-glycosylation-mutated HCV envelope glycoprotein complex enhances antigen-presenting activity and cellular and neutralizing antibody responses. Biochim Biophys Acta, 1860(8): 1764-1775.
10.Luo W, Qu ZL, Xie Y, Xiang J, Zhang XL*. (2015) Identification of a novel immunodominant antigen Rv2645 from RD13 with potential as a cell-mediated immunity-based TB diagnostic agent. J Infect, 71(5):534-543.
11.Tang XL, Zhou YX, Wu SM, Pan Q, Xia B, Zhang XL*. (2014) CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents. J Infect, 69: 569-580.
12.Tang XL, Yuan CH, Ding QQ, Zhou YD, Pan Q, Zhang XL*. (2017) Selection and identification of specific glycoproteins and glycan biomarkers of macrophages involved in Mycobacterium tuberculosis infection. Tuberculosis (Edinb), 104: 95-106.
13.Pan Q, Yan J, Liu Q, Yuan C, Zhang XL*. (2017) An ssDNA aptamer against mannose-capped lipoarabinomannan enhances anti-tuberculosis activity of macrophages through downregulation of lipid-sensing nuclear receptor peroxisome proliferator-activated receptor γ expression. Microbiol Immunol. 2017, 61: 92-102.
14.Luo F, Chen T, Liu J, Shen X, Zhao Y, Yang R, Zhang XL*. (2016) Ficolin-2 binds to HIV-1 gp120 and blocks viral infection. Virol Sin. 2016 Oct;31(5):406-414.
15.Chen T, Hu Y, Ding Q, Yu J, Wang F, Luo F, Zhang XL*. (2015) Serum ficolin-2 concentrations are significantly changed in patients with hepatitis B virus infection and liver diseases. Virol Sin, 2015, 30(4):249-60.
16.Ding F, Guo S, Xie M, Luo W, Yuan C, Huang W, Zhou Y, Zhang XL*, and Zhou X*. (2015) Diagnostic applications of gastric carcinoma cell aptamers in vitro and in vivo. Talanta, 134:30-36.